刘潇璇教授个人简介

刘潇璇19813月生。博士、教授、博士生导师。20106月获得中国武汉大学化学专业博士学位,同年8月获得法国艾克斯-马赛大学化学专业博士学位;20109月至20155月,先后在法国健康与医学研究中心马赛癌症研究所和法国国家科学院马赛纳米交叉科学研究中心从事研究工作,主持法国前列腺癌症研究协会和法国抗肌肉疾病研究协会的博士后基金项目;2015被评为江苏特聘教授、中国药科大学高层次人才引进特聘教授,2016年入选国家第十二批“千人计划”青年项目。

从事科研工作以来,成功的结合了化学、物理、生物和医学等学科的优势,设计开发了各类功能化和智能化的新型树形分子,并对其在作为核酸药物的纳米给药载体方面的应用进行了一系列深入的研究,并取得了许多开创性的研究成果,其中一类结构柔顺类的树形分子正计划进行进一步的临床测试。其研究成果已在《AngewandteChemie International Edition》、《Proceedings of the National Academy of Sciences》、《Nanoscale》、《Nanomedicine: Nanotechnology, Biology and Medicine》、《Journal of Medicinal Chemistry》和《Mol. Pharmaceutical》等国际学术刊物上发表学术论文25篇,被《Nauture Chemistry》作为亮点报道,同时也在其它期刊作为卷首或封面故事报道。与此同时,还兼职《ACS Nano》、《ACS Catalysis》、《Nanomedicine: NBM》、《New Journal of Chemistry》、《ChemBioChem》工作。

 

主要研究方向:

1.  药物化学:高分子前药

2. 药剂学:药用高分子材料与靶向释药系统研究、基因药物的递送

 

代表性论文:

1.          Tuo Wei, Chao Chen, Juan Liu, Cheng Liu, Paola Posocco, Xiaoxuan Liu, Qiang Cheng, ShuaidongHuo, Zicai Liang, Maurizio Fermeglia, Sabrina Pricl, Xing-Jie Liang, Palma Rocchi, Ling Peng, “Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance”, Proc. Natl. Acad. Sci.2015, 112, 2978-2783. (影响因子9.67)

2.    Xiaoxuan Liu*,Cheng Liu, Jiehua Zhou, Chao Chen, Fanqi Qu,John J. Rossi,Palma Rocchi, Ling Peng*, “Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrimer”, Nanoscale2015, 7, 3867-3875. (影响因子7.394*共通讯作者)

3.          Xiaoxuan Liu, Jiehua Zhou, Tianzhu Yu, Chao Chen, Qiang Cheng, KheyaSengupta, Yuanyu Huang, Haitang Li, Cheng Liu, Yang Wang, Paola Posocco, Menghua Wang, Qi Cui, Suzanne Giorgio,Maurizio Fermeglia, Fanqi Qu, Sabrina Pricl, Yanhong Shi, Zicai Liang, Palma Rocchi, John J. Rossi, Ling Peng, “Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems”,Angew. Chem. Int. Ed.2014, 53, 11822-11827.(影响因子11.336) (Nature Chemistry亮点报道)

4.          Xiaoxuan Liu, Cheng Liu, Carlo V. Catapano, Ling Peng, Jiehua Zhou, Palma Rocchi, “Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics”, Biotechnol. Adv. 2014, 32, 844-852. (影响因子9.015)

5.          Xiaoxuan Liu, Cheng Liu, Chao Chen, MélanieBentobji, Francine AzarioCheillan, Jeanne ThomassinPiana, Fanqi Qu, Palma Rocchi, Ling Peng, “Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system”,Nanomedicine:Nanotechnology, Biology and Medicine2014, 10, 1627-1636. (影响因子6.155)

6.    Cheng Liu, Xiaoxuan Liu*, Palma Rocchi, Fanqi Qu, Juan L. Iovanna, Ling Peng*, “An arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo”, Bioconjugate Chem. 2014, 25, 521-532. (影响因子4.513*共通讯作者)

7.          Tianzhu Yu1, Xiaoxuan Liu1, Anne-Laure Bolcato-Bellemin, Yang Wang, Cheng Liu, Patrick Erbacher, Fangqi Qu, Palma Rocchi, Jean-Paul Behr, Ling Peng, “An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo”, Angew. Chem. Int. Ed. 2012, 51, 8478-8484. (影响因子11.3361共第一作者) (卷首文章)

8.          Xiaoxuan Liu, Cheng Liu, Erik Laurini, Paola Posocco, Sabrina Pricl, Fanqi Qu, Palma Rocchi, Ling Peng, “Efficient delivery of sticky siRNA and potent gene silencing in a prostate cancer model using a generation 5 triethanolamine-core PAMAM dendrimer”, Mol. Pharmaceutics 2012, 9, 470-481. (影响因子4.384封面文章)

 

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