吴晓明教授个人简介

  

 

 

吴晓明,男,1954年生,药学博士,教授,博导

 

研究方向:天然产物的合成、优化与评价研究。

简历:1997年--2013年任中国药科大学校长。

兼任中国药学会副理事长、中国医药教育协会副会长、中国高等医学教育学会副会长、第五届教育部科学技术委员会学部委员、国家新药评审委员、江苏省科技进步奖评选委员会委员、教育部药学类专业教学指导委员会主任委员,江苏省药学会名誉理事长,第十一届江苏省人大代表、全国医药院校药学类教材编委会主任、《中国天然药物》等多家医药杂志、期刊的主编、副主编、编委和特邀编委。

吴晓明课题组主要从事抗肿瘤、抗心血管疾病药物、抗糖尿病药物的药物化学研究,在不对称合成反应的基础研究、新型非肽类血管紧张素(Ⅱ)(AⅡ)受体拮抗剂、新型-葡萄糖苷酶抑制剂等具有生理活性的天然产物的全合成及构效关系等方面进行了大量的研究工作。先后主持和参加国家“863”计划、国家“新药创制”科技重大专项, 国家自然科学基金面上项目等多项国家及省部级科研课题及多项国家重点教改课题,在本学科重要杂志:Chem Commun, Org Lett, Eur J Med Chem, BMC, BMCL, Tetrahedron, Tetrahedron Lett等国内外学术刊物上发表学术论文70多篇,两次获国家级教学成果一等奖,两次获江苏省教学成果特等奖,获江苏省科技进步一等奖、国家留学回国人员成就奖,全国留学回国人员先进个人等,为国务院政府特殊津贴专家。

 

 
近期代表性SCI论文
1. Renren Bai, Jie Liu, Yao Zhu, Xue Yang, Chen Yang, Lingyi Kong, Xiaobing Wang, Hengyuan Zhang, Hequan Yao, Mingqin Shen, Xiaoming Wu*, Jinyi Xu*. Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3- methyl-isochromanone-4. Bioorganic & Medicinal Chemistry Letters, 2012, 22(20), 6490-6493.
2. Renren Bai, Xue Yang, Yao Zhu, Zhiwen Zhou, Weijia Xie, Hequan Yao, Jieyun Jiang, Jie Liu, Mingqin Shen, Xiaoming Wu*, Jinyi Xu*. Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity. Bioorganic & Medicinal Chemistry, 2012, 20(23), 6848-6855.
3. Renren Bai, Zhen Wei, Jie Liu, Weijia Xie, Hequan Yao, Xiaoming Wu*, Jieyun Jiang, Qiujuan Wang, Jinyi Xu*. Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists. Bioorganic & Medicinal Chemistry, 2012, 20(15), 4661-4667.
4. Fei Sun; Peiqing Zhu; Hequan Yao; Xiaoming Wu*; Jinyi Xu*. A partial synthesis of 23-hydroxybetulonic acid and 23-hydroxybetulinic acid starting from betulinic acid. Journal of Chemical Research, 2012, 36, 254-257.
5. Dahong Li, Hao Cai, Bowen Jiang, Guyue Liu, Yuetong Wang, Lei Wang, Hequan Yao, Xiaoming Wu*, Yijun Sun, Jinyi Xu*. Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells. European Journal of Medicinal Chemistry, 2013, 59, 322-328.
6. Yi Bi, Jinyi Xu*, Fei Sun, Xiaoming Wu*, Wencai Ye, Yijun Sun, Wenwen Huang. Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates. Molecules, 2012, 17(8) , 8832-8841.
7. Ziyuan Li, Ling Ma, JinyiXu, Lingyi Kong, Xiaoming Wu*, Hequan Yao*. Pd(II)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage. Chemical Communications, 2012, 48(31), 3763-3765.
8. Lei Zhao, Ziyuan Li, Lin Chang, JinyiXu, Hequan Yao*, Xiaoming Wu*. Efficient Construction of Fused Indolines with a 2-Quaternary Center via an Intramolecular Heck Reaction with a Low Catalyst Loading. Organic Letters, 2012, 68(14), 2066-2069.
9. Lijun Ni, Ziyuan Li, Fan Wu, JinyiXu, Xiaoming Wu, Lingyi Kong, Hequan Yao*. Concise total syntheses of Marinoquinolines A-C. Tetrahedron Letters, 2012, 53(10), 1271-1274.
10. Yue Huang, XiaodongZu, Fan Wu, JinyiXu, Xiaoming Wu*, Hequan Yao*. Efficient Construction of Fused Indolines with a 2-Quaternary Center via an Intramolecular Heck Reaction with a Low Catalyst Loading. Tetrahedron, 2012, 14(8), 3123-3128.
11. Renren Bai, Xue Yang, Wen Hong, Yiqun Tang, Shengtao Xu, Hequan Yao, Jieyun Jiang, Jie Liu, Mingqin Shen, Xiaoming Wu*, Jinyi Xu*. Novel hybrids of natural isochroman-4-one bearing N- substituted isopropanolamine as potential antihypertensive candidates. Bioorganic & Medicinal Chemistry, 2013, 21, 2495-2502.

12. Dan Liu, Weijia Xie*, Long Liu, Hequan Yao, Jinyi Xu, Genzoh Tanabe, Osamu Muraoka, Xiaoming Wu*. Tetrahedron Lett. 2013, 54, 6333-6336.