莫然教授个人简介

 

 

 

  莫然,男,1983年11月生。博士、教授、博士生导师。2012年获得中国药科大学药剂学专业博士学位;2012年10月至2014年10月在美国北卡罗来纳大学教堂山分校从事博士后研究员工作(Research Fellow);2014年10月获中国药科大学海外高层次人才引进计划,全职回国工作。

 

    从事科研工作以来,紧密结合药剂学、材料学、生物医学工程、化学等交叉专业背景的优势,围绕治疗及诊断用“智能纳米药物递送系统”的研究热点,取得了一系列标志性、创新性的重要研究成果。以第一作者或通讯作者已在《Nature Communications》、《Chemical Society Reviews》、《Angewandte Chemie International Edition》、《Advanced Materials》、《Advanced Functional Materials》、《Biomaterials》等国际一流专业期刊上发表学术论文12篇,累积影响因子120。并已申请多项美国和中国专利,其中一项中国专利已授权。
 
 
主要研究方向:
1. 病灶微环境调控式纳米药物递送系统(Pathological Microenvironment-Modulated Nanosystem for Drug Delivery)
2. 靶向能量代谢的疾病诊疗药物递送系统(Metabolism-Targeted Drug Delivery System for Disease Theranostics)
3. 生理信号触发式药物智能释放系统(Physiological Signal-Activated Nanostructure for Controlled Drug Release)
 
代表性论文:
1. Ran Mo, Tianyue Jiang, Rocco DiSanto, Wanyi Tai, Zhen Gu*, “ATP-Triggered Anticancer Drug Deilivery”, Nature Communications, 2014, 5, 3364. (IF: 10.742)
2. Ran Mo*, Tianyue Jiang, Zhen Gu*, “Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery”, Angewandte Chemie International Edition, 2014, 53, 5815-5820. (IF: 11.336; 兼通讯作者)
3. Caoyun Ju, Ran Mo*, Jingwei Xue, Lei Zhang, Zekai Zhao, Lingjing Xue, Can Zhang*, “Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration”, Angewandte Chemie International Edition, 2014, 53, 6253-6258. (IF: 11.336; 并列第一作者兼通讯作者, VIP文章, 封面文章)
4. Ran Mo, Tianyue Jiang, Jin Di, Wanyi Tai, Zhen Gu*, “Emerging Micro- and Nanotechnology based Synthetic Approaches for Insulin Delivery”, Chemical Society Reviews, 2014, 43, 3595-3629. (IF: 30.425)
5. Tianyue Jiang, Ran Mo, Adriano Bellotti, Jianping Zhou, Zhen Gu*, “Gel-Liposome-Mediated Co-Delivery of Anticancer Membrane-Associated Proteins and Small-Molecule Drugs for Enhanced Therapeutic Efficacy”, Advanced Functional Materials, 2013, 24, 2295-2304. (IF: 10.439; 并列第一作者, 封面文章)
6. Wanyi Tai, Ran Mo, Yue Lu, Tianyue Jiang, Zhen Gu*, “Folding Graft Copolymer with Pedant Drug Segment for Co-Delivery of Anticancer Drugs”, Biomaterials, 2014, 35, 7194-7203. (IF: 8.312; 并列第一作者)
7. Ran Mo, Qiong Sun, Nan Li, Can Zhang*, “Intracellular Delivery and Antitumor Effects of pH-Sensitive Liposomes based on Zwitterionic Oligopeptide Lipids”, Biomaterials, 2013, 34, 2773-2786. (IF: 8.312)
8. Ran Mo, Qiong Sun, Jingwei Xue, Nan Li, Wenyuan Li, Can Zhang*, Qineng Ping, “Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery”, Advanced Materials, 2012, 24, 3659-3665. (IF: 15.409; 封面文章)
9. Ran Mo, Xiang Jin, Nan Li, Caoyun Ju, Minjie Sun, Can Zhang*, Qineng Ping, “The Mechanism of Enhancement on Oral Absorption of Paclitaxel by N-Octyl-O-sulfate Chitosan Micelles”, Biomaterials, 2011, 32, 4609-4620. (IF: 8.312)
 
联系方式:

Email:rmo@cpu.edu.cn; rmocpu@163.com