甄乐副研究员个人简介

 

甄乐博士,副研究员,硕士生导师

2010年毕业于青岛大学医学院药学专业;2015年毕业于中国药科大学,获药物化学专业博士学位,同年留校任教;2018年任副研究员。现任职于中国药科大学药物代谢动力学重点实验室。目前主要基于核苷类药物及天然活性分子的药代动力学特征,开展创新药物分子的设计、合成及生物活性研究。

研究方向:基于药代动力学的创新药物分子发现

科研项目:主持国自然青年基金一项、省自然青年基金一项、中央高校基本科研业务费项目一项。参与重大新药创制专项一项、国自然基金五项。

研究成果

1.Zhen Le, Dai Liang, Wen Xiaoan, Yao Lan, Jin Xiaoliang, Yang Xiao-Wen, Zhao Wenfeng, Yu Sheng-Qi, Yuan Haoliang, Wang Guangji, Sun Hongbin, Discovery of Novel Nucleotide Prodrugs with Improved Potency Against HCV Variants Carrying NS5B S282T Mutation, Journal of Medicinal Chemistry, 2017, 60, 6077-6088.

2.Zhen Le, Wang Jiankun, Xu Qing-Long, Sun Hongbin, Wen Xiaoan, Wang Guangji, Direct Intermolecular C–H Functionalization Triggered by 1, 5-Hydride Shift: Access to N-Arylprolinamides via Ugi-Type Reaction, Organic Letters, 2017, 19, 1566-1569.

3.Lin Chao, Zhen Le (coauther), Cheng Yong, Du Hong-Jin, Zhao Hui, Wen Xiaoan, Kong Ling-Yi, Xu Qing-Long, Sun Hongbin, Visible-Light Induced Isoindoles Formation To Trigger Intermolecular Diels–Alder Reactions in the Presence of Air, Organic Letters, 2015, 17, 2684-2687.

4.Wang Jiankun, Sun Yilin, Wang Guangji, Zhen Le*, DEAD-Promoted Oxidative Ugi-Type Reaction Including an Unprecedented Ugi Amidation Assisted by Dicarboxylic Acids, European Journal of Organic Chemistry, 2017, 6338-6348.

5.Zhen Le, Dai Liang, Yu Sheng-Qi, Lin Chao, Sun Hongbin, Xu Qing-Long, Reaction Pathways through a [1, 5]-Hydride Shift Triggered by Acids: Approach to Bridged-Ring Heterocycles and Polycycles, European Journal of Organic Chemistry, 2017, 560-569.

联系方式13951729372i_m_zhenle@163.com

南京市鼓楼区童家巷24号,中国药科大学,科研大楼808室,邮编:210009