张惠斌研究员个人简介

张惠斌女,1964年12月出生。1984年本科毕业于南京药学院制药化学专业,1989年和2004年在中国药科大学分别获得药物化学硕士和博士学位1989年起在中国药科大学新药研究中心长期从事新药研究和开发工作。负责国家自然科学基金、国家重大新药创制专项、江苏省产学研联合创新项目等。负责完成3项江苏省自然科学基金项目课题负责完成多名硕士和博士研究生的论文指导工作。是国家自然科学基金和保健品评审专家负责申请专利20多项,获得授权专利9项,发表论文90余篇。

  

研究领域:抗代谢性疾病药物研究,主要针对代谢性疾病及肿瘤新靶点的创新药物研究。


代表性论文

1. Junhao Xing, Lingyun Yang, Yifei Yang, Leilei Zhao, Qiangqiang Wei, Jian Zhang,Jinpei Zhou, Huibin Zhang*. Design, synthesis and biological evaluation of novel 2,3-dihydroquinazolin-4(1H)-one derivatives as potential fXa inhibitors. European Journal of Medicinal Chemistry, 2017,125,411-422.

2. Leilei Zhao, Yifei Yang, Yahui Guo, Lingyun Yang, Jian Zhang, Jinpei Zhou*, Huibin Zhang*. Design, synthesis and biological evaluation of 7-methylimidazo [1,5-a]pyrazin-8 (7H)-one derivatives as BRD4 inhibitors. Bioorganic & Medicinal Chemistry, 2017, 25(8), 2482-2490.

3. Lingyun Yang, Li Han, Bin Xu, Leilei Zhao, Jinpei Zhou, and Huibin Zhang*. Palladium-Catalyzed C−HBondOrthoAcylation/AnnulationwithTolueneDerivatives Toluene Derivatives.Asian Journal of Organic Chemistry, 2016, 5 (1): 62-65 .

4. Xing J, Yang L, Li H, Li Q, Zhao L, Wang X, Zhang Y, Zhou M, Zhou J, Zhang H*. Identification of anthranilamide derivatives as potential factor Xa inhibitors: drug design, synthesis and biological evaluation. Eur J Med Chem, 2015 5; 95: 388-99

5. Li Q, Zhou M, Han L, Cao Q, Wang X, Zhao L, Zhou J, Zhang H*. Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors. Chem Biol Drug Des,  2015, 86(4): 849-56

6. Xing J, Li Q, Zhang S, Liu H, Zhao L, Cheng H, Zhang Y, Zhou J, Zhang H*. Identification of Dipeptidyl Peptidase IV Inhibitors: Virtual Screening, Synthesis and Biological Evaluation. Chem Biol Drug Des. 2014 , 84(3):364-77.

7. Li Q, Hu Q, Wang X, Zong Y, Zhao L, Xing J, Zhou J, Zhang H*. Discovery of Novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents. Chem Biol Drug Des. 2015, 86(4):509-16.

8. Huibin Zhang, Yaan Zhang, Guanzhong Wu, Jinpei Zhou, Wenlong Huang, Xiaowen Hu, Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents , Bioorganic & Medicinal Chemistry Letters, 2009, 19(6), 1740-1744

9. Jing Li, Huibin Zhang,*, Wenlong Huang, Hai Qian and Ying Li. TNF-Inhibitors with Anti-Oxidative Stress Activity from Natural Products. Current Topics in Medicinal Chemistry, 2012, 12, 1408-1421

10. Huibin Zhang, Yaan Zhang, Guanzhong Wu, Jinpei Zhou, Wenlong Huang, Xiaowen Hu, Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents , Bioorganic & Medicinal Chemistry Letters, 2009, 19(6), 1740-1744

11. Yubin Wang, Hai Qian, Jinpei Zhou, Huibin Zhang*, and Jianfeng Ji and Wenlong Huang. Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors. Medicinal Chemistry, 2011, 7, 534-542

12. Wenyuan Liu, Ainan Zhoua, Feng Feng, Huibin Zhang*, Jinpei Zhou, Wenlong Huang. Qualitative and quantitative studies on impurities in G004, a potential hypoglycaemic agent, using liquid chromatography, nuclear magnetic resonance and mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56, 627-632

13. Hui Bin Zhang, Yu Shi Chi, Wen Long Huang, Shuai Jian Ni. Total synthesis of human urotension-II by microwave-assisted solid phase method. Chinese Chemical Letters, 2007, 18 : 902–904.

14. Yushi Chi, Huibin Zhang*, Wenlong Huang, Jinpei Zhou, Yinghong Zhou, Hai Qian, Shuaijian Ni. Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7–36) amideBioorganic & Medicinal Chemistry, 2008, 16 (16),7607-7614

15. Chi, Yushi; Zhang, Huibin*; Zhou, Jinpei; Huang, Wenlong; Ni, Shuaijian, Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues, Letters in Organic Chemistry, 2008 5(5),399-402(4)

16. Yu Li, Hui-bin Zhang*, Wen-long Huang, Yun-man Li Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancerBioorganic & Medicinal Chemistry Letters, 2008, 18(12),3652-3655

17. Jing Li, Wenlong Huang, Huibin Zhang*, Xinyang Wang, Huiping Zhou. Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activitiesBioorganic & Medicinal Chemistry Letters, 2007,17(24) , 6891-689

  

联系方式:Email: zhanghb80@163.com